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T-box transcription factor TBX21, also called T-bet (T-box expressed in T cells) is a protein that in 1️⃣ humans is encoded by the TBX21 gene.
T-bet positively regulates the secretion of IFN- to regulate immune responses. Through inducing the expression of Zeb2, T-bet promoted 1️⃣ the differentiation from immature NK cells to mature NK cells.
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